(19)
(11) EP 0 543 938 A1

(12)

(43) Date of publication:
02.06.1993 Bulletin 1993/22

(21) Application number: 91916802.0

(22) Date of filing: 13.08.1991
(51) International Patent Classification (IPC): 
A61K 31/ 70( . )
A61P 31/ 12( . )
C07K 14/ 11( . )
C12N 15/ 113( . )
A61K 48/ 00( . )
A61P 31/ 16( . )
C12N 15/ 09( . )
A61K 38/ 00( . )
(86) International application number:
PCT/US1991/005742
(87) International publication number:
WO 1992/003454 (05.03.1992 Gazette 1992/06)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 14.08.1990 US 19900567287

(71) Applicant: ISIS PHARMACEUTICALS, INC.
Carlsbad, CA 92008 (US)

(72) Inventors:
  • COWSERT, Lex, M.
    Carlsbad, CA 92008 (US)
  • ECKER, David, J.
    Carlsbad, CA 92009 (US)

(74) Representative: Hallybone, Huw George 
CARPMAELS AND RANSFORD 43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) INHIBITION OF INFLUENZA VIRUS TYPE A, ANN ARBOR STRAIN H2N2 BY ANTISENSE OLIGONUCLEOTIDES