(19)

(11)

EP 0 544 657 A1

(12)

(43) Date of publication: 09.06.1993 Bulletin 1993/23 (21) Application number: 90912514.0 (22) Date of filing: 21.08.1990

(51) International Patent Classification (IPC):  C07B 61/ 00( . ) A61K 8/ 00( . ) A61K 8/ 33( . ) A61K 8/ 40( . ) A61K 8/ 46( . ) A61K 8/ 58( . ) A61K 8/ 65( . ) A61K 8/ 86( . ) A61K 9/ 10( . ) A61K 9/ 14( . ) A61K 49/ 04( . ) B01J 2/ 06( . ) C07C 67/ 00( . ) A01N 25/ 12( . ) A61K 8/ 02( . ) A61K 8/ 34( . ) A61K 8/ 42( . ) A61K 8/ 49( . ) A61K 8/ 64( . ) A61K 8/ 73( . ) A61K 9/ 00( . ) A61K 9/ 107( . ) A61K 9/ 16( . ) A61Q 90/ 00( . ) C07B 31/ 00( . ) C09B 67/ 00( . ) (86) International application number: PCT/US1990/004735 (87) International publication number: WO 1992/003380 (05.03.1992 Gazette 1992/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (71) Applicant: THE UNIVERSITY OF ROCHESTER Rochester, New York 14627 (US)	(72) Inventors: VIOLANTE, Michael, R. Rochester, NY 14623 (US) FISCHER, Harry, W. Pittsford, NY 14534 (US) (74) Representative: Thomas, Roger Tamlyn  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)