(19)
(11) EP 0 544 668 A1

(12)

(43) Date of publication:
09.06.1993 Bulletin 1993/23

(21) Application number: 91904744.0

(22) Date of filing: 08.02.1991
(51) International Patent Classification (IPC): 
A61K 31/ 52( . )
A61P 31/ 12( . )
C07D 473/ 00( . )
C07F 9/ 09( . )
C07H 19/ 16( . )
 A61K 31/ 675( . )
A61P 37/ 04( . )
C07D 473/ 40( . )
C07F 9/ 6561( . )
(86) International application number:
PCT/US1991/000886
(87) International publication number:
WO 1991/012260 (22.08.1991 Gazette 1991/19)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 09.02.1990 US 19900477406

(71) Applicants:
  • THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
    Washington, DC 20002 (US)
  • SANYO KOKUSAKU PULP CO. LTD.
    Iwakuni 740 (JP)

(72) Inventors:
  • MITSUYA, Hiroaki
    T-2 Rockville, MD 20852 (US)
  • SHIRASAKA, Takuma
    Rockville, MD 20852 (US)
  • BRODER, Samuel
    Bethesda, MD 20814 (US)
  • MURAKAMI, Kunichika
    Iwakuni-shi, Yamaguchi-ken 740 (JP)
  • YOSHIOKA, Hidetoshi,Sanyo-Kokusaku Pulp Co. Ltd.
    Iwakuni-shi, Yamaguchi-ken 740 (JP)
  • KOJIMA, Eiji
    Iwakuni-shi, Iwakuni 740 (JP)

(74) Representative: Jump, Timothy John Simon, et al 
Venner Shipley & Co. 20 Little Britain
London EC1A 7DH
London EC1A 7DH (GB)

   


(54) 6-HALO- AND 2-AMINO-6-HALO-PURINE 2',3'-DIDEOXY NUCLEOSIDES AND THEIR USE AS ANTIVIRAL AGENTS