(19)

(11)

EP 0 544 685 A1

(12)

(43) Date of publication: 09.06.1993 Bulletin 1993/23 (21) Application number: 91912483.0 (22) Date of filing: 13.07.1991

(51) International Patent Classification (IPC):  C07K 14/ 445( . ) C12N 15/ 74( . ) C12N 15/ 30( . ) A61K 39/ 00( . ) (86) International application number: PCT/EP1991/001332 (87) International publication number: WO 1992/001796 (06.02.1992 Gazette 1992/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 19.07.1990 GB 19900015888 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS s.a. B-1330 Rixensart (BE)	(72) Inventors: JACOBS, Paul B-7800 Lanquesaint (BE) HAESELEER, Françoise B-1480 Tubize (BE) MASSAER, Marc B-1440 Wauthier-Braine (BE) BOLLEN, Alex B-1701 Itterbeek (BE) (74) Representative: Tyrrell, Arthur William Russell, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)