(19)

(11)

EP 0 544 815 A1

(12)

(43) Date of publication: 09.06.1993 Bulletin 1993/23 (21) Application number: 91916882.0 (22) Date of filing: 17.07.1991

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 38/ 36( . ) A61P 7/ 00( . ) A61P 9/ 08( . ) A61P 11/ 16( . ) A61P 29/ 00( . ) C07K 7/ 08( . ) C07K 14/ 42( . ) C07K 16/ 00( . ) C07K 16/ 28( . ) C08B 37/ 00( . ) C12N 15/ 09( . ) G01N 33/ 53( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) A61P 7/ 02( . ) A61P 9/ 10( . ) A61P 19/ 02( . ) A61P 35/ 04( . ) C07K 14/ 00( . ) C07K 14/ 705( . ) C07K 16/ 18( . ) C07K 16/ 46( . ) C12N 15/ 02( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1991/005059 (87) International publication number: WO 1992/001718 (06.02.1992 Gazette 1992/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 17.07.1990 US 19900554199 05.02.1991 US 19910650484 (60) Divisional application: 01204837.7 / 1245575 (60) Divisional application: 95202380.2 / 0714912 (71) Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA Norman, Oklahoma 73109 (US)	(72) Inventor: MCEVER, Rodger, P. Oklahoma City, OK 73120 (US) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)