(19)

(11)

EP 0 544 898 A1

(12)

(43) Date of publication: 09.06.1993 Bulletin 1993/23 (21) Application number: 92915038.0 (22) Date of filing: 25.06.1992

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1992/005424 (87) International publication number: WO 1993/000588 (07.01.1993 Gazette 1993/02)

(84) Designated Contracting States: DE FR GB (30) Priority: 26.06.1991 US 19910721760 (71) Applicants: The Biomembrane Institute Seattle Washington 98119 (US) SAITO, Daizo Shibata-shi, Niigata-ken 957-01 (JP)	(72) Inventors: SAITO, Daizo Shibata-shi, Niigata-ken 957-01 (JP) HAKOMORI, Sen-itiroh Mercer Island, WA 98040 (US) KIMURA, Satoshi Seattle, WA 98119 (US) (74) Representative: Brown, John David, et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)