PRODUCTION OF HUMAN LYSOZYME IN METHYLOTROPHIC YEAST CELLS AND EFFICIENT SECRETION THEREFROM - Patent 0547171

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EP 0 547 171 A1

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(43)	Date of publication:
	23.06.1993 Bulletin 1993/25

(21)	Application number: 91918484.0

(22)	Date of filing: 04.09.1991

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International Patent Classification (IPC):

C07K 14/ 395^{( . )}
C12N 9/ 36^{( . )}
C12N 15/ 81^{( . )}

C12N 1/ 19^{( . )}
C12N 15/ 09^{( . )}
C12R 1/ 84^{( . )}

(86)	International application number:
	PCT/US1991/006326

(87)	International publication number:
	WO 1992/004441 (19.03.1992 Gazette 1992/07)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

05.09.1990 US 19900577994

(71)	Applicant: THE SALK INSTITUTE BIOTECHNOLOGY INDUSTRIAL ASSOCIATES, INC.
	La Jolla, California 92037-4641 (US)

(72)	Inventors:
	DAVIS, Geneva, Ruth San Diego, CA 92111 (US) STILLMAN, Cathy, Ann San Diego, CA 92109 (US) BRIERLEY, Russell, Arthur San Diego, CA 92126 (US) THILL, Gregory, Patrick San Diego, CA 92111 (US) VEDVICK, Thomas, Scott Carlsbad, CA 92009 (US)

(74)	Representative: Allard, Susan Joyce, et al
	BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)

(54)	PRODUCTION OF HUMAN LYSOZYME IN METHYLOTROPHIC YEAST CELLS AND EFFICIENT SECRETION THEREFROM