(19)

(11)

EP 0 548 110 A1

(12)

(43) Date of publication: 30.06.1993 Bulletin 1993/26 (21) Application number: 91915223.0 (22) Date of filing: 16.05.1991

(51) International Patent Classification (IPC):  A23L 1/ 275( . ) A61K 31/ 785( . ) C09B 69/ 10( . ) C12P 17/ 10( . ) A61K 8/ 72( . ) A61Q 17/ 04( . ) C12P 17/ 00( . ) (86) International application number: PCT/US1991/003464 (87) International publication number: WO 1992/016189 (01.10.1992 Gazette 1992/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 25.10.1990 US 19900603111 25.03.1991 US 19910674489 (71) Applicant: YALE UNIVERSITY New Haven, CT 06510 (US)	(72) Inventors: PAWELEK, John, M. Hamden, CT 06517 (US) ORLOW, Seth, J. Long Island City, NY 11106 (US) (74) Representative: Cohausz & Florack Patentanwälte  Postfach 33 02 29 D-40435 Düsseldorf D-40435 Düsseldorf (DE)