(19)

(11)

EP 0 548 145 A1

(12)

(43) Date of publication: 30.06.1993 Bulletin 1993/26 (21) Application number: 91916009.0 (22) Date of filing: 05.09.1991

(51) International Patent Classification (IPC):  A61K 9/ 06( . ) A61K 9/ 107( . ) A61P 17/ 00( . ) C07C 59/ 64( . ) A61K 9/ 08( . ) A61K 31/ 19( . ) A61P 29/ 00( . ) (86) International application number: PCT/GB1991/001509 (87) International publication number: WO 1992/004019 (19.03.1992 Gazette 1992/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 05.09.1990 GB 19900019413 (71) Applicant: BEECHAM GROUP plc Brentford Middlesex TW8 9EP (GB)	(72) Inventors: GREENWAY, M. J., SmithKline Beecham Pharmac. West Sussex BN14 8QH (GB) BLOWER, P. R., SmithKline Beecham Pharmaceut. Essex CM19 5AD (GB) (74) Representative: Russell, Brian John  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)