(19)

(11)

EP 0 548 252 A1

(12)

(43) Date of publication: 30.06.1993 Bulletin 1993/26 (21) Application number: 91917491.0 (22) Date of filing: 05.09.1991

(51) International Patent Classification (IPC):  A61K 39/ 012( . ) C07K 14/ 455( . ) C12P 21/ 02( . ) C12R 1/ 90( . ) A61P 33/ 02( . ) C12N 15/ 09( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1991/006431 (87) International publication number: WO 1992/004461 (19.03.1992 Gazette 1992/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 12.09.1990 US 19900581694 (71) Applicants: GENEX CORPORATION Gaithersburg Maryland 20877 (US) HOECHST AKTIENGESELLSCHAFT D-60386 Frankfurt am Main (DE)

(72) Inventors: JACOBSON, James, W. Rockville, MD 20850 (US) STRAUSBERG, Robert, L. Silver Spring, MD 20906 (US) WILSON, Susan, D. Rockville, MD 20853 (US) POPE, Sharon, H. Gaithersburg, MD 20879 (US) STRAUSBERG, Susan, Lee Silver Spring, MD 20906 (US) RAETHER, Wolfgang D-6072 Dreieich (DE) (74) Representative: Roberts, Alison Christine, et al  Kilburn & Strode, 30 John Street London WC1N 2DD London WC1N 2DD (GB)