(19)

(11)

EP 0 549 598 A1

(12)

(43) Date of publication: 07.07.1993 Bulletin 1993/27 (21) Application number: 91914266.0 (22) Date of filing: 05.08.1991

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) C07D 471/ 04( . ) A61P 7/ 02( . ) (86) International application number: PCT/EP1991/001491 (87) International publication number: WO 1992/003434 (05.03.1992 Gazette 1992/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 17.08.1990 GB 19900018139 (71) Applicants: Pfizer Limited Sandwich Kent CT13 9NJ (GB) PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventor: FRAY, Michael, Jonathan Pfizer Central Research Sandwich Kent CT13 9NJ (GB) (74) Representative: Bradbrook, Geoffrey William, et al  PFIZER LIMITED Ramsgate Road Sandwich Kent, CT13 9NJ Sandwich Kent, CT13 9NJ (GB)