(19)

(11)

EP 0 549 600 A1

(12)

(43) Date of publication: 07.07.1993 Bulletin 1993/27 (21) Application number: 91914561.0 (22) Date of filing: 29.07.1991

(51) International Patent Classification (IPC):  A61K 31/ 42( . ) A61K 31/ 425( . ) A61P 3/ 08( . ) A61P 27/ 02( . ) C07D 263/ 48( . ) C07D 403/ 12( . ) C07D 413/ 12( . ) C12N 9/ 99( . ) A61K 31/ 421( . ) A61K 31/ 44( . ) A61P 3/ 10( . ) A61P 43/ 00( . ) C07D 403/ 04( . ) C07D 413/ 04( . ) C07D 417/ 12( . ) (86) International application number: PCT/US1991/005172 (87) International publication number: WO 1992/005163 (02.04.1992 Gazette 1992/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 17.09.1990 US 19900583425 (71) Applicant: PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventors: CLARK, David, A. East Lyme, CT 06333 (US) HOWARD, Harry, R. Bristol, CT 06010 (US) (74) Representative: Wood, David John, et al  PFIZER LIMITED, Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)