(19)

(11)

EP 0 549 662 A1

(12)

(43) Date of publication: 07.07.1993 Bulletin 1993/27 (21) Application number: 91916716.0 (22) Date of filing: 19.09.1991

(51) International Patent Classification (IPC):  A61K 39/ 015( . ) A61P 31/ 00( . ) C07K 14/ 44( . ) C07K 16/ 00( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) A61K 39/ 00( . ) A61K 39/ 395( . ) C07K 14/ 435( . ) C07K 14/ 445( . ) C07K 16/ 20( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) C12R 1/ 19( . ) (86) International application number: PCT/GB1991/001605 (87) International publication number: WO 1992/005193 (02.04.1992 Gazette 1992/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 19.09.1990 GB 19900020438 (71) Applicant: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE London SW7 2BB (GB)	(72) Inventors: SINDEN, Robert, Edward 96 Woosehill Road Berkshire RG11 2TS (GB) SUHRBIER, A., Queensland Inst. of Medical Res. Brisbane, QLD 4006 (AU) WINGER, Larry, Aldon Buckinghamshire (GB) (74) Representative: Lambert, Hugh Richmond, et al  D. YOUNG & CO., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)