(19)

(11)

EP 0 550 465 A1

(12)

(43) Date of publication: 14.07.1993 Bulletin 1993/28 (21) Application number: 91915391.0 (22) Date of filing: 21.08.1991

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61P 31/ 00( . ) C07K 14/ 005( . ) C07K 14/ 44( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) C07K 14/ 00( . ) C07K 14/ 195( . ) C07K 14/ 705( . ) C07K 16/ 20( . ) C12N 15/ 02( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1991/005979 (87) International publication number: WO 1992/003457 (05.03.1992 Gazette 1992/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 24.08.1990 US 19900572916 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: AGABIAN, Nina, Martha San Francisco, CA 94115 (US) EDMAN, Ursula San Francisco, CA 94114 (US) GOMEZ-PALACIO, Isaura, Meza Mexico, D.F. 03920 (MX) (74) Representative: Kirschner, Klaus Dieter, Dipl.-Phys., et al  Forstenrieder Allee 59 D-81476 München D-81476 München (DE)