(19)

(11)

EP 0 550 531 A1

(12)

(43) Date of publication: 14.07.1993 Bulletin 1993/28 (21) Application number: 91916841.0 (22) Date of filing: 20.09.1991

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) (86) International application number: PCT/GB1991/001618 (87) International publication number: WO 1992/005280 (02.04.1992 Gazette 1992/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 21.09.1990 GB 19900020621 (71) Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED London WC2A 3NL (GB)	(72) Inventors: LENNON, Gregory Glenn 44 Lincoln's Inn Fields, London WC2A 3PX (GB) LEHRACH, Hans Rudolph 44 Lincoln's Inn Fields, London WC2A 3PX (GB) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)