(19)

(11)

EP 0 550 558 A1

(12)

(43) Date of publication: 14.07.1993 Bulletin 1993/28 (21) Application number: 91917103.0 (22) Date of filing: 27.09.1991

(51) International Patent Classification (IPC):  A61K 39/ 10( . ) C07K 14/ 235( . ) A61P 31/ 04( . ) A61K 39/ 00( . ) (86) International application number: PCT/GB1991/001669 (87) International publication number: WO 1992/005798 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 27.09.1990 GB 19900021004 (60) Divisional application: 96110147.4 / 0764445 (71) Applicant: MEDEVA HOLDINGS BV NL-1078 ED Amsterdam (NL)	(72) Inventors: CHARLES, Ian, George Langley Court Beckenham Kent BR3 3BS (GB) FAIRWEATHER, Neil, Fraser Langley Court Beckenham Kent BR3 3 BS (GB) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)