(19)

(11)

EP 0 550 559 A1

(12)

(43) Date of publication: 14.07.1993 Bulletin 1993/28 (21) Application number: 91917114.0 (22) Date of filing: 23.09.1991

(51) International Patent Classification (IPC):  A61K 31/ 52( . ) A61P 37/ 08( . ) A61K 31/ 522( . ) C07D 473/ 06( . ) (86) International application number: PCT/GB1991/001634 (87) International publication number: WO 1992/005176 (02.04.1992 Gazette 1992/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 26.09.1990 GB 19900020921 (71) Applicant: Beecham Group p.l.c. Brentford Middlesex TW8 9BD (GB)

(72) Inventors: BUCKLE, Derek, Richard SmithKline Beecham Epsom Surrey KT18 5XQ (GB) SMITH, David, Glynn SmithKline Beecham Epsom Surrey KT18 5XQ (GB) FENWICK, Ashley, Edward SmithKline Beecham Epsom Surrey KT18 5XQ (GB) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)