(19)

(11)

EP 0 550 595 A1

(12)

(43) Date of publication: 14.07.1993 Bulletin 1993/28 (21) Application number: 91917436.0 (22) Date of filing: 18.09.1991

(51) International Patent Classification (IPC):  A61K 31/ 395( . ) A61K 31/ 445( . ) A61P 3/ 08( . ) A61K 31/ 40( . ) A61K 31/ 55( . ) A61P 3/ 10( . ) (86) International application number: PCT/US1991/006778 (87) International publication number: WO 1992/004899 (02.04.1992 Gazette 1992/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 24.09.1990 US 19900587322 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406 (US)	(72) Inventor: BADGER, Alison, Mary Bryn Mawr, PA 19010 (US) (74) Representative: Giddings, Peter John, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)