(19)

(11)

EP 0 551 321 A1

(12)

(43) Date of publication: 21.07.1993 Bulletin 1993/29 (21) Application number: 91917032.0 (22) Date of filing: 30.09.1991

(51) International Patent Classification (IPC):  A61K 8/ 30( . ) A61K 8/ 34( . ) A61K 8/ 92( . ) A61K 47/ 00( . ) A61K 47/ 14( . ) A61Q 5/ 00( . ) A61Q 19/ 00( . ) A61K 8/ 00( . ) A61K 8/ 63( . ) A61K 31/ 565( . ) A61K 47/ 10( . ) A61P 17/ 00( . ) A61Q 7/ 00( . ) C07J 1/ 00( . ) (86) International application number: PCT/GB1991/001677 (87) International publication number: WO 1992/005763 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 04.10.1990 GB 19900021546 (71) Applicant: Beecham Group p.l.c. Brentford Middlesex TW8 9BD (GB)

(72) Inventors: RIDGE, Benjamin Digby, SmithKline Beecham Weybridge, Surrey KT13 0DE (GB) SHAW, Michael Ian, SmithKline Beecham Weybridge, Surrey KT13 0DE (GB) CARTER, Timothy Peter, SmithKline Beecham Weybridge, Surrey KT13 0DE (GB) DAVIS, Walter Brian Ashtead, Surrey KT21 1DD (GB) (74) Representative: Dalton, Marcus Jonathan William  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)