(19)

(11)

EP 0 551 400 A1

(12)

(43) Date of publication: 21.07.1993 Bulletin 1993/29 (21) Application number: 91918758.0 (22) Date of filing: 02.10.1991

(51) International Patent Classification (IPC):  A61K 35/ 12( . ) A61P 29/ 00( . ) C07K 16/ 42( . ) C12P 21/ 08( . ) A61K 39/ 395( . ) C07K 16/ 28( . ) C12N 15/ 02( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1991/007365 (87) International publication number: WO 1992/006119 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 03.10.1990 US 19900592147 (71) Applicant: BOEHRINGER INGELHEIM PHARMACEUTICALS INC. Ridgefield, Connecticut 06877-0368 (US)	(72) Inventors: BARTON, Randall Farmington, CT 06032 (US) CZAJKOWSKI, Michele 55 Wildman Street Danbury, CT 06810 (US) KENNEDY, Charles Waterbury, CT 06706 (US) Rothlein, Robert Danbury, CT 06811 (US) (74) Representative: Roberts, Alison Christine, et al  Kilburn & Strode, 30 John Street London WC1N 2DD London WC1N 2DD (GB)