(19)

(11)

EP 0 551 442 A1

(12)

(43) Date of publication: 21.07.1993 Bulletin 1993/29 (21) Application number: 92901703.0 (22) Date of filing: 04.10.1991

(51) International Patent Classification (IPC):  A61K 31/ 35( . ) A61K 33/ 24( . ) A61K 39/ 395( . ) A61K 45/ 00( . ) A61P 35/ 00( . ) A61K 31/ 47( . ) A61K 38/ 00( . ) A61K 39/ 44( . ) A61P 31/ 00( . ) (86) International application number: PCT/US1991/007292 (87) International publication number: WO 1992/005803 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: DE FR GB (30) Priority: 04.10.1990 US 19900592926 (71) Applicant: THE SCRIPPS RESEARCH INSTITUTE La Jolla, CA 92037 (US)	(72) Inventor: RIDEOUT, Darryl, C. San Diego, CA 92126 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)