(19)

(11)

EP 0 552 185 A1

(12)

(43) Date of publication: 28.07.1993 Bulletin 1993/30 (21) Application number: 91917056.0 (22) Date of filing: 01.10.1991

(51) International Patent Classification (IPC):  C07F 9/ 24( . ) C07H 21/ 04( . ) C07H 21/ 00( . ) C12Q 1/ 68( . ) (86) International application number: PCT/GB1991/001687 (87) International publication number: WO 1992/006103 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 04.10.1990 GB 19900021625 (71) Applicant: IMPERIAL CHEMICAL INDUSTRIES PLC London SW1P 3JF (GB)	(72) Inventors: HOLLAND, David Macclesfield, Cheshire SK11 6TR (GB) GARMAN, Andrew John Ashton, Chester CH3 8DE (GB) EDGE, Michael Derek Congleton, Cheshire CW12 4AS (GB) MCLEAN, Michael Joseph Crewe, Cheshire CW2 8TA (GB) (74) Representative: Locke, Timothy John, Dr., et al  ICI Bio Products & Fine Chemicals PO Box 1 GB-Billingham, Cleveland TS23 1LB GB-Billingham, Cleveland TS23 1LB (GB)