(19)

(11)

EP 0 552 297 A1

(12)

(43) Date of publication: 28.07.1993 Bulletin 1993/30 (21) Application number: 91920333.0 (22) Date of filing: 09.10.1991

(51) International Patent Classification (IPC):  C07K 14/ 18( . ) C07K 14/ 02( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12N 15/ 02( . ) G01N 33/ 576( . ) A61K 39/ 00( . ) C07K 14/ 00( . ) C07K 14/ 10( . ) C07K 16/ 10( . ) C12N 7/ 02( . ) C12P 21/ 08( . ) G01N 33/ 577( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1991/007571 (87) International publication number: WO 1992/007001 (30.04.1992 Gazette 1992/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 12.10.1990 US 19900596811 (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: MILLER, Mahlon, F. Libertyville, IL 60048 (US) LESNIEWSKI, Richard, R. Kenosha, WI 53142 (US) PETERSON, David, A. Bristol, WI 53104 (US) BRYCE, Warren, Hugh Zion, IL 60099 (US) (74) Representative: Modiano, Guido, Dr.-Ing.  Modiano & Associati S.r.l. Via Meravigli 16 I-20123 Milan I-20123 Milan (IT)