(19)

(11)

EP 0 553 194 A1

(12)

(43) Date of publication: 04.08.1993 Bulletin 1993/31 (21) Application number: 91918580.0 (22) Date of filing: 20.09.1991

(51) International Patent Classification (IPC):  A61K 9/ 20( . ) A61K 31/ 80( . ) A61P 1/ 04( . ) A61K 31/ 695( . ) A61K 33/ 10( . ) (86) International application number: PCT/US1991/006857 (87) International publication number: WO 1992/004889 (02.04.1992 Gazette 1992/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 21.09.1990 US 19900586481 (71) Applicant: Beecham Inc. Philadelphia, PA 19101 (US)	(72) Inventors: AGNOLI, Robert Alan Andover, NJ 07821 (US) ELLEGOOD, Michelle Geraldine Millstadt, IL 62260 (US) SMALLEY, Ronald Matthew Parsipany, NJ 07054 (US) CUCA, Robert C. Edwardsville, IL 62025 (US) (74) Representative: White, Susan Mary  SmithKline Beecham plc Corporate Intellectual Property SB House L/5 Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)