(19)
(11) EP 0 553 244 B8

(12) CORRECTED NEW EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B2)

(48) Corrigendum issued on:
08.06.2005 Bulletin 2005/23

(45) Date of publication and mentionof the opposition decision:
06.04.2005 Bulletin 2005/14

(45) Mention of the grant of the patent:
30.12.1998 Bulletin 1998/53

(21) Application number: 91919595.8

(22) Date of filing: 04.10.1991
(51) International Patent Classification (IPC)7A61K 39/21, A61K 39/29, A61K 39/42
// A61K39/00, A61K39/395, A61K39/40
(86) International application number:
PCT/US1991/007283
(87) International publication number:
WO 1992/005793 (16.04.1992 Gazette 1992/09)

(54)

TARGETED IMMUNOSTIMULATION WITH BISPECIFIC REAGENTS

GEZIELTE IMMUNOSTIMULIERUNG MIT BISPEZIFISCHEN STOFFEN

IMMUNOSTIMULATION CIBLEE INDUITE PAR DES REACTIFS BISPECIFIQUES


(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 05.10.1990 US 593083

(43) Date of publication of application:
04.08.1993 Bulletin 1993/31

(73) Proprietors:
  • Celldex Therapeutics, Inc.
    Bloomsbury, NJ 08804 (US)
  • ROMET-LEMONNE, Jean Loup
    F-91190 Gif-Yvette (FR)

(72) Inventors:
  • ROMET-LEMONNE, Jean, Loup
    F-91190 Gif-Yvette (FR)
  • FANGER, Michael, W.
    Lebanon, NH 03766 (US)

(74) Representative: Kirkham, Nicholas Andrew 
Graham Watt & Co LLP St Botolph's House 7-9 St Botolph's Road
Sevenoaks Kent TN13 3AJ
Sevenoaks Kent TN13 3AJ (GB)


(56) References cited: : 
EP-A- 0 308 936
WO-A-91/00360
WO-A-88/00052
US-A- 4 950 480
   
  • SONGSIVILAI ET AL: 'A NOVEL STRATEGY FOR PRODUCING CHIMERIC BISPECIFIC ANTIBODIES BY GENE TRANSFECTION' BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS vol. 164, 1989, NEW YORK,USA, pages 271 - 276, XP001194767
  • CELIS ET AL: 'REGULATION OF T-CELL FUNCTION BY ANTIBODIES:ENHANCEMENT OF THE RESPONSE OF HUMAN T-CELL CLONES TO HEPATITIS B SURFACE ANTIGEN BY ANTIGEN-SPECIFIC MONOCLONAL ANTIBODIES' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES,USA vol. 81, 1984, WASHINGTON D.C.,USA, pages 6846 - 6850, XP001194785
  • Snider et al: 1990, Journal of Experimental Medicin, 171, 1957-1963
  • Shen et al: 1986, Journal of Immunology, 137, 3378-3382
  • Kawamura; Berzofsky: 1986, Journal of Immunology, 136, 58-65