(19)

(11)

EP 0 554 358 A1

(12)

(43) Date of publication: 11.08.1993 Bulletin 1993/32 (21) Application number: 91919986.0 (22) Date of filing: 26.09.1991

(51) International Patent Classification (IPC):  A61K 51/ 00( . ) A61K 49/ 04( . ) A61K 51/ 10( . ) C07K 1/ 113( . ) C07K 17/ 00( . ) G01N 33/ 532( . ) A61K 47/ 48( . ) A61K 51/ 04( . ) A61P 35/ 00( . ) C07K 16/ 00( . ) G01N 33/ 531( . ) (86) International application number: PCT/US1991/007016 (87) International publication number: WO 1992/005804 (16.04.1992 Gazette 1992/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 27.09.1990 US 19900588816 (71) Applicant: BRUNSWICK CORPORATION Skokie Illinois 60077 (US)	(72) Inventors: WRASIDLO, Wolfgang, J. La Jolla, CA 92037 (US) SILVEIRA, Michael, H. Encinitas, CA 92024 (US) (74) Representative: Holmes, Michael John  Frank B. Dehn & Co. European Patent Attorneys Imperial House 15-19 Kingsway London, WC2B 6UZ, London, WC2B 6UZ, (GB)