(19)

(11)

EP 0 555 251 A1

(12)

(43) Date of publication: 18.08.1993 Bulletin 1993/33 (21) Application number: 91918092.0 (22) Date of filing: 18.10.1991

(51) International Patent Classification (IPC):  A61K 31/ 425( . ) A61P 3/ 06( . ) A61P 3/ 10( . ) C07D 277/ 34( . ) A61K 31/ 426( . ) A61P 3/ 08( . ) C07D 277/ 20( . ) C07D 417/ 12( . ) (86) International application number: PCT/GB1991/001834 (87) International publication number: WO 1992/007838 (14.05.1992 Gazette 1992/11)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 30.10.1990 GB 19900023583 (71) Applicant: BEECHAM GROUP plc Brentford Middlesex TW8 9EP (GB)	(72) Inventors: 1AIGH, David SmithKline Beecham Pharmaceuticals Epsom Surrey KT18 5XQ (GB) BELL, David SmithKline Beecham Pharmaceuticals Harlow Essex CM19 5AD (GB)