(19)

(11)

EP 0 555 255 A1

(12)

(43) Date of publication: 18.08.1993 Bulletin 1993/33 (21) Application number: 91918200.0 (22) Date of filing: 29.10.1991

(51) International Patent Classification (IPC):  C12N 9/ 04( . ) C12Q 1/ 32( . ) C12Q 1/ 00( . ) (86) International application number: PCT/FI1991/000324 (87) International publication number: WO 1992/007953 (14.05.1992 Gazette 1992/11)

(84) Designated Contracting States: CH DE DK FR GB LI SE (30) Priority: 29.10.1990 FI 19900005324 (71) Applicant: VALTION TEKNILLINEN TUTKIMUSKESKUS SF-02150 Espoo (FI)	(72) Inventors: BUCHERT, Johanna SF-02160 Espoo (FI) SMOLANDER, Maria SF-02760 Espoo (FI) VIIKARI, Liisa SF-00200 Helsinki (FI) (74) Representative: Säfwenberg, Björn, et al  Axel Ehrners Patentbyra AB Box 10316 S-100 55 Stockholm S-100 55 Stockholm (SE)