(19)

(11)

EP 0 555 347 A1

(12)

(43) Date of publication: 18.08.1993 Bulletin 1993/33 (21) Application number: 91920258.0 (22) Date of filing: 30.10.1991

(51) International Patent Classification (IPC):  A61K 31/ 47( . ) C07D 471/ 14( . ) A61P 31/ 12( . ) (86) International application number: PCT/US1991/008028 (87) International publication number: WO 1992/007856 (14.05.1992 Gazette 1992/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 31.10.1990 US 19900606216 25.10.1991 US 19910783063 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406 (US)

(72) Inventors: ALLAUDEEN, Hameed, Sheik North Potomac, MD 20278 (US) BERGES, David, Alan Phoenixville, PA 19460 (US) HERTZBERG, Robert, Philip Downingtown, PA 19335 (US) JOHNSON, Randall, Keith Ardmore, PA 19003 (US) KINGSBURY, William, Dennis Wayne, PA 19087 (US) PETTEWAY, Stephen, Robert, Jr. West Chester, PA 19382 (US) (74) Representative: Tocher, Pauline, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)