(19)

(11)

EP 0 555 418 A1

(12)

(43) Date of publication: 18.08.1993 Bulletin 1993/33 (21) Application number: 92905487.0 (22) Date of filing: 30.10.1991

(51) International Patent Classification (IPC):  C07K 17/ 00( . ) C07K 16/ 00( . ) G01N 33/ 569( . ) C07K 1/ 22( . ) G01N 33/ 53( . ) (86) International application number: PCT/US1991/008080 (87) International publication number: WO 1992/007952 (14.05.1992 Gazette 1992/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 30.10.1990 US 19900605647 (71) Applicants: IMMULOGIC PHARMACEUTICAL CORPORATION Cambridge Massachusetts 02139 (US) MERCK & CO. INC. Rahway New Jersey 07065-0900 (US)

(72) Inventors: ROTHBARD, Jonathan, B. Atherton, CA 94027 (US) WICKER, Linda, S. Scotch Plains, NJ 07076 (US) CUBBON, Rose, M. Fanwood, NJ 07023 (US) NICHOLS, Elizabeth, A. Westfield, NJ 07093 (US) BUSCH, Robert, Inst. für Immunologie und Genetik W-6900 Heidelberg (DE) VAN SCHOOTEN, Wim Palo Alto, CA 94304 (US) HILL, Mark, C. Palo Alto, CA 94306 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)