(19)
(11) EP 0 556 285 A1

(12)

(43) Date of publication:
25.08.1993 Bulletin 1993/34

(21) Application number: 92900028.0

(22) Date of filing: 18.10.1991
(51) International Patent Classification (IPC): 
A61K 31/ 40( . )
A61K 39/ 395( . )
A61K 31/ 70( . )
A61P 35/ 00( . )
(86) International application number:
PCT/US1991/007767
(87) International publication number:
WO 1992/007466 (14.05.1992 Gazette 1992/11)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 05.11.1990 US 19900609557

(71) Applicant: Bristol-Myers Squibb Company
New York, N.Y. 10154 (US)

(72) Inventors:
  • HELLSTRÖM, Ingegerd
    Seattle, WA 98105 (US)
  • HELLSTRÖM, Karl, Erik
    Seattle, WA 98105 (US)
  • SCHREIBER, George
    Redmond, WA 98052 (US)

(74) Representative: Jones, Alan John, et al 
CARPMAELS & RANSFORD 43 Bloomsbury Square
London, WC1A 2RA
London, WC1A 2RA (GB)

   


(54) SYNERGISTIC THERAPY WITH COMBINATIONS OF ANTI-TUMOR ANTIBODIES AND BIOLOGICALLY ACTIVE AGENTS