(19)

(11)

EP 0 556 405 A1

(12)

(43) Date of publication: 25.08.1993 Bulletin 1993/34 (21) Application number: 92917987.0 (22) Date of filing: 19.08.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 5/ 02( . ) C07K 5/ 08( . ) C07K 7/ 02( . ) G01N 33/ 53( . ) A61P 37/ 00( . ) C07K 5/ 06( . ) C07K 5/ 10( . ) C07K 14/ 66( . ) (86) International application number: PCT/JP1992/001046 (87) International publication number: WO 1993/004080 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 26.08.1991 US 19910749886 03.08.1992 US 19920920601 (71) Applicant: Japan Tobacco Inc. Shinagawa-ku, Tokyo 140 (JP)	(72) Inventors: DEGRAW, Joseph, I. Sunnyvale, CA 94087 (US) ALMQUIST, Ronald Palo Alto, CA 94301 (US) HIEBERT, Charles San Jose, CA 95136 (US) SMITH, R., Lane Palo Alto, CA 94306-2618 (US) UCHIDA, Itsuo, Pharmaceutical Research Laboratory Yokohama-shi, Kanagawa-ken 227 (JP) (74) Representative: Reinhard - Skuhra - Weise & Partner  Postfach 44 01 51 D-80750 München D-80750 München (DE)