(19)

(11)

EP 0 557 273 A1

(12)

(43) Date of publication: 01.09.1993 Bulletin 1993/35 (21) Application number: 90917617.0 (22) Date of filing: 15.11.1990

(51) International Patent Classification (IPC):  C07K 14/ 72( . ) A61K 38/ 00( . ) C12N 15/ 12( . ) (86) International application number: PCT/US1990/006533 (87) International publication number: WO 1992/008726 (29.05.1992 Gazette 1992/12)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (71) Applicant: UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Bethesda, MD 20892-9902 (US)

(72) Inventors: AKAMIZU, Takashi Fushimi-ku Kyoto 612 (JP) IKUYAMA, Shoichiro Chuo-ku Fukuoka 810 (JP) SAJI, Motoyasu Rockville, MD 20852 (US) KOSUGI, Shinji Rockville, MD 20852 (US) BAN, Toshiaki Rockville, MD 20852 (US) KOHN, Leonard, D. Bethesda, MD 20814 (US) (74) Representative: Thomson, Paul Anthony, et al  Potts, Kerr & Co. 15, Hamilton Square Birkenhead Merseyside L41 6BR Birkenhead Merseyside L41 6BR (GB)