(19)

(11)

EP 0 557 388 A1

(12)

(43) Date of publication: 01.09.1993 Bulletin 1993/35 (21) Application number: 91920470.0 (22) Date of filing: 14.11.1991

(51) International Patent Classification (IPC):  A61K 39/ 155( . ) A61P 31/ 12( . ) C07K 14/ 76( . ) C07K 16/ 10( . ) C12N 5/ 10( . ) C12N 7/ 00( . ) C12N 7/ 02( . ) C12N 15/ 09( . ) G01N 33/ 53( . ) G01N 33/ 577( . ) A61K 39/ 395( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) C12N 5/ 12( . ) C12N 7/ 01( . ) C12N 15/ 02( . ) C12P 21/ 08( . ) G01N 33/ 569( . ) (86) International application number: PCT/AU1991/000519 (87) International publication number: WO 1992/008785 (29.05.1992 Gazette 1992/12)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 14.11.1990 AU 19900003352 (71) Applicant: THE UNIVERSITY COMPANY PTY. LTD. Murdoch, W.A. 6150 (AU)	(72) Inventor: COOK, Robert, David Mundijong, W.A. 6202 (AU) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Bakers Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)