(19)
(11) EP 0 557 408 A1

(12)

(43) Date of publication:
01.09.1993 Bulletin 1993/35

(21) Application number: 92900087.0

(22) Date of filing: 05.11.1991
(51) International Patent Classification (IPC): 
A61K 31/ 415( . )
A61K 31/ 425( . )
A61K 31/ 4409( . )
A61K 31/ 443( . )
A61K 31/ 495( . )
A61K 31/ 535( . )
A61P 35/ 00( . )
C07C 217/ 58( . )
C07C 271/ 20( . )
C07D 213/ 38( . )
C07D 233/ 36( . )
C07D 309/ 10( . )
C07D 335/ 02( . )
C07D 401/ 06( . )
C07D 405/ 14( . )
C07D 409/ 14( . )
C07D 417/ 14( . )
A61K 31/ 4166( . )
A61K 31/ 44( . )
A61K 31/ 4418( . )
A61K 31/ 4433( . )
A61K 31/ 505( . )
A61P 29/ 00( . )
A61P 37/ 08( . )
C07C 271/ 02( . )
C07C 271/ 34( . )
C07D 233/ 32( . )
C07D 307/ 20( . )
C07D 333/ 32( . )
C07D 401/ 04( . )
C07D 405/ 12( . )
C07D 409/ 12( . )
C07D 417/ 12( . )
(86) International application number:
PCT/US1991/008229
(87) International publication number:
WO 1992/007567 (14.05.1992 Gazette 1992/11)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 06.11.1990 US 19900609990
06.11.1990 US 19900609981

(71) Applicant: SMITHKLINE BEECHAM CORPORATION
King of Prussia, PA 19406 (US)

(72) Inventors:
  • BENDER, Paul, Elliot
    Cherry Hill, NJ 08003 (US)
  • CHRISTENSEN, Siegfried, Benjamin, IV
    Philadelphia, PA 19103 (US)

(74) Representative: Rutter, Keith, Dr., et al 
SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road
Brentford, Middlesex TW8 9BD
Brentford, Middlesex TW8 9BD (GB)

   


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