(19)

(11)

EP 0 558 645 A1

(12)

(43) Date of publication: 08.09.1993 Bulletin 1993/36 (21) Application number: 92901253.0 (22) Date of filing: 12.11.1991

(51) International Patent Classification (IPC):  A61K 9/ 50( . ) A61P 7/ 04( . ) C07K 14/ 00( . ) C07K 14/ 75( . ) C07K 19/ 00( . ) G01N 33/ 48( . ) A61K 35/ 18( . ) C07K 1/ 113( . ) C07K 14/ 705( . ) C07K 16/ 00( . ) C12N 5/ 06( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1991/008430 (87) International publication number: WO 1992/008804 (29.05.1992 Gazette 1992/12)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 09.11.1990 US 19900611164 (71) Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK Albany, New York 12201-0009 (US)	(72) Inventor: COLLER, Barry, S. Dix Hills, NY 11746 (US) (74) Representative: Hirsch, Marc-Roger, et al  Cabinet Hirsch 34 rue de Bassano F-75008 Paris F-75008 Paris (FR)