(19)

(11)

EP 0 559 724 A1

(12)

(43) Date of publication: 15.09.1993 Bulletin 1993/37 (21) Application number: 92900144.0 (22) Date of filing: 28.11.1991

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61K 31/ 415( . ) A61P 9/ 12( . ) A61P 15/ 00( . ) A61P 27/ 02( . ) C07D 307/ 79( . ) C07D 333/ 28( . ) C07D 405/ 10( . ) C07D 409/ 06( . ) A61K 31/ 4025( . ) A61P 9/ 00( . ) A61P 13/ 02( . ) A61P 25/ 00( . ) A61P 43/ 00( . ) C07D 307/ 82( . ) C07D 405/ 06( . ) C07D 405/ 14( . ) (86) International application number: PCT/GB1991/002114 (87) International publication number: WO 1992/009600 (11.06.1992 Gazette 1992/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 29.11.1990 GB 19900026006 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)

(72) Inventors: ROSS, Barry, Clive Glaxo Group Research Limited Hertfordshire SG12 0DG (GB) SCOPES, David, Ian, Carter Hertfordshire SG12 0DG (GB) CARDWELL, Kevin, Stuart Hertfordshire SG12 0DG (GB) ELDRED, Colin, David Glaxo Group Research Limited Hertfordshire SG12 0DG (GB) MIDDLEMISS, David Glaxo Group Research Limited Hertfordshire SG12 0DG (GB) JACK, Torquil, Iain, MacLean Hertfordshire SG12 0DG (GB) DOWLE, Michael, Dennis Hertfordshire SG12 0DG (GB) MONTANA, John, Gary Glaxo Group Research Limited Hertfordshire SG12 0DG (GB) SHAH, Pritom Glaxo Group Research Limited Ware Hertfordshire SG12 0DG (GB) (74) Representative: James, Stephen Richard, Dr., et al  Glaxo plc Glaxo House Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)