(19)

(11)

EP 0 561 898 A1

(12)

(43) Date of publication: 29.09.1993 Bulletin 1993/39 (21) Application number: 92900699.0 (22) Date of filing: 12.12.1991

(51) International Patent Classification (IPC):  C07D 207/ 24( . ) C07D 211/ 72( . ) C07D 401/ 06( . ) C07D 487/ 04( . ) C07D 207/ 27( . ) C07D 211/ 76( . ) C07D 471/ 04( . ) C07D 207/ 26( . ) (86) International application number: PCT/GB1991/002209 (87) International publication number: WO 1992/010499 (25.06.1992 Gazette 1992/14)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 12.12.1990 GB 19900026926 (71) Applicant: SMITH KLINE & FRENCH LABORATORIES LIMITED Welwyn Garden City Hertfordshire, AL7 1EY (GB)

(72) Inventors: ARMITAGE, Mark A., SmithKline Beecham Pharm. Leigh, Nr. Tonbridge, Kent TN11 9AN (GB) HAYES, Jerome, F., SmithKline Beecham Pharm. Leigh, Nr. Tonbridge, Kent TN11 9AN (GB) MITCHELL, Michael B., SmithKline Beecham Pharm. Leigh, Nr. Tonbridge, Kent TN11 9AN (GB) PROCTER, Garry, Dep. of Chem. Salford M5 4NT (GB) (74) Representative: Thompson, Clive Beresford  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)