(19)

(11)

EP 0 563 036 A1

(12)

(43) Date of publication: 06.10.1993 Bulletin 1993/40 (21) Application number: 91901866.0 (22) Date of filing: 21.12.1990

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61P 25/ 28( . ) A61P 25/ 00( . ) C07D 487/ 08( . ) (86) International application number: PCT/GB1990/002016 (87) International publication number: WO 1992/011261 (09.07.1992 Gazette 1992/17)

(84) Designated Contracting States: CH DE FR GB IT LI NL (71) Applicant: MERCK SHARP & DOHME LTD. Hoddesdon Hertfordshire EN11 9NU (GB)	(72) Inventors: MACLEOD, Angus M. Stortford, Hertfordshire CM23 4JR (GB) HERBERT, Richard Broxbourne, Hertfordshire EN10 7JU (GB) HOOGSTEEN, Karst Rahway, NJ 07065 (US) (74) Representative: Barrett-Major, Julie Diane, et al  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow Essex CM20 2QR Harlow Essex CM20 2QR (GB)