(19)

(11)

EP 0 563 048 A1

(12)

(43) Date of publication: 06.10.1993 Bulletin 1993/40 (21) Application number: 91917474.0 (22) Date of filing: 28.03.1991

(51) International Patent Classification (IPC):  A61K 9/ 12( . ) A61K 31/ 19( . ) C07B 53/ 00( . ) C07C 323/ 56( . ) A61K 9/ 00( . ) A61P 11/ 00( . ) C07C 319/ 20( . ) (86) International application number: PCT/US1991/002177 (87) International publication number: WO 1992/011236 (09.07.1992 Gazette 1992/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 19.12.1990 US 19900630114 25.01.1991 US 19910645850 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)

(72) Inventors: MILOSOVICH, Susan, Marie Phoenixville, PA 19460 (US) RANDALL, Cynthia, Shea Philadelphia, PA 19128 (US) RENCHER, William, Franklin Devon, PA 19333 (US) ROSSI, Thomas, Mark Dowingtown, PA 19335 (US) GOMBATZ, Kerry, Joseph West Chester, PA 19382 (US) (74) Representative: Giddings, Peter John, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)