(19)

(11)

EP 0 563 304 A1

(12)

(43) Date of publication: 06.10.1993 Bulletin 1993/40 (21) Application number: 92903756.0 (22) Date of filing: 19.12.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 25/ 00( . ) C07K 14/ 475( . ) C07K 16/ 18( . ) A61K 39/ 395( . ) C07K 14/ 435( . ) C07K 16/ 00( . ) G01N 33/ 53( . ) (86) International application number: PCT/US1991/009650 (87) International publication number: WO 1992/011026 (09.07.1992 Gazette 1992/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 21.12.1990 US 19900632431 (71) Applicant: CASE WESTERN RESERVE UNIVERSITY Cleveland, OH 44106 (US)	(72) Inventors: RAO, Mahendra, S. Cleveland, OH 44120 (US) LANDIS, Story, C. Shaker Heights, OH 44122 (US) (74) Representative: Hirsch, Marc-Roger, et al  Cabinet Hirsch 34 rue de Bassano F-75008 Paris F-75008 Paris (FR)