(19)

(11)

EP 0 565 638 A1

(12)

(43) Date of publication: 20.10.1993 Bulletin 1993/42 (21) Application number: 92904479.0 (22) Date of filing: 03.01.1992

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C07K 14/ 47( . ) C12N 15/ 09( . ) A61K 48/ 00( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) (86) International application number: PCT/US1992/000295 (87) International publication number: WO 1992/011874 (23.07.1992 Gazette 1992/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 04.01.1991 US 19910637563 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)	(72) Inventors: DONEHOWER, Lawrence, A. Houston, TX 11096 (US) BRADLEY, Allan Houston, TX 77096 (US) BUTEL, Janet, S. Houston, TX 77025 (US) SLAGLE, Betty Houston, TX 77008 (US) (74) Representative: Armitage, Ian Michael, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)