(19)

(11)

EP 0 566 611 A1

(12)

(43) Date of publication: 27.10.1993 Bulletin 1993/43 (21) Application number: 92902189.0 (22) Date of filing: 08.01.1992

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61P 15/ 00( . ) C07K 7/ 23( . ) C07K 16/ 00( . ) C07K 16/ 42( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) G01N 33/ 53( . ) G01N 33/ 74( . ) A61K 39/ 395( . ) C07K 7/ 08( . ) C07K 14/ 575( . ) C07K 16/ 26( . ) C07K 19/ 00( . ) C12N 15/ 16( . ) C12P 21/ 08( . ) G01N 33/ 68( . ) (86) International application number: PCT/GB1992/000040 (87) International publication number: WO 1992/012247 (23.07.1992 Gazette 1992/19)

(84) Designated Contracting States: AT BE CH DE ES FR GR IT LI LU MC NL SE (30) Priority: 09.01.1991 GB 19910000468 (71) Applicant: PROTEUS MOLECULAR DESIGN LIMITED Macclesfield, Cheshire SK11 0JL (GB)	(72) Inventors: FISHLEIGH, Robert Vincent Macclesfield, Cheshire SK11 0HD (GB) ROBSON, Barry Marple, Cheshire SK6 5AA (GB) (74) Representative: Hildyard, Edward Martin, et al  Frank B. Dehn & Co. European Patent Attorneys Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)