(19)

(11)

EP 0 568 539 A1

(12)

(43) Date of publication: 10.11.1993 Bulletin 1993/45 (21) Application number: 92900254.0 (22) Date of filing: 06.11.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 31/ 04( . ) C07K 14/ 00( . ) C07K 14/ 705( . ) C07K 16/ 18( . ) C12N 15/ 09( . ) G01N 33/ 53( . ) A61K 39/ 395( . ) A61P 31/ 12( . ) C07K 14/ 47( . ) C07K 16/ 00( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1991/008320 (87) International publication number: WO 1992/007579 (14.05.1992 Gazette 1992/11)

(84) Designated Contracting States: BE CH DE DK ES FR GB IT LI NL SE (30) Priority: 06.11.1990 US 19900609915 (71) Applicant: The Children's Medical Center Corporation Boston, Massachusetts 02115 (US)	(72) Inventor: EZEKOWITZ, Raymond, Alan, Brian Boston, MA 02116 (US) (74) Representative: Deans, Michael John Percy, et al  Lloyd Wise, Tregear & CO. Norman House 105-109 Strand London WC2R OAE London WC2R OAE (GB)