(19)

(11)

EP 0 569 414 A1

(12)

(43) Date of publication: 18.11.1993 Bulletin 1993/46 (21) Application number: 92903462.0 (22) Date of filing: 28.01.1992

(51) International Patent Classification (IPC):  C07C( . ) A61K 31/ 165( . ) C07C 65/ 26( . ) C07C 255/ 57( . ) C07C 311/ 46( . ) C07C 323/ 42( . ) C07D 213/ 75( . ) C07C 235/ 38( . ) A61K 31/ 18( . ) C07C 235/ 56( . ) C07C 255/ 60( . ) C07C 317/ 40( . ) C07C 327/ 48( . ) (86) International application number: PCT/GB1992/000153 (87) International publication number: WO 1992/012961 (06.08.1992 Gazette 1992/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 28.01.1991 GB 19910017772 16.08.1991 GB 19910177279 (71) Applicant: RHONE POULENC RORER LIMITED Dagenham, Essex RM10 XS (GB)

(72) Inventors: ASHTON, Michael, John Rhône-Poulenc Rorer Limited Dagenham Essex RM10 7XS (GB) COOK, David, Charles Rhône-Poulenc Rorer Limited Dagenham Essex RM10 7XS (GB) FENTON, Garry Rhône-Poulenc Rorer Limited Dagenham Essex RM10 7XS (GB) HILLS, Susan, Jacqueline Dagenham Essex RM10 7XS (GB) MCFARLANE, Ian, Michael Dagenham Essex RM10 7XS (GB) PALFREYMAN, Malcolm, Norman Dagenham Essex RM10 7XS (GB) RATCLIFFE, Andrew, James Dagenham Essex RM10 7XS (GB) VICKER, Nigel Rhône-Poulenc Rorer Limited Dagenham Essex RM10 7XS (GB) (74) Representative: Bentham, Stephen  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)