(19)

(11)

EP 0 570 507 A1

(12)

(43) Date of publication: 24.11.1993 Bulletin 1993/47 (21) Application number: 92906660.0 (22) Date of filing: 05.02.1992

(51) International Patent Classification (IPC):  A61K 31/ 195( . ) A61K 31/ 381( . ) A61K 38/ 00( . ) A61P 7/ 02( . ) A61P 9/ 10( . ) C07D 209/ 44( . ) C07D 333/ 16( . ) C07K 5/ 02( . ) C07K 5/ 08( . ) C07K 5/ 10( . ) A61K 31/ 38( . ) A61K 31/ 415( . ) A61K 38/ 46( . ) A61P 9/ 00( . ) C07C 279/ 14( . ) C07D 233/ 00( . ) C07D 333/ 20( . ) C07K 5/ 06( . ) C07K 5/ 09( . ) (86) International application number: PCT/US1992/000999 (87) International publication number: WO 1992/013552 (20.08.1992 Gazette 1992/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 05.02.1991 US 19910650527 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)

(72) Inventors: ALI, Fadia El-Fehail Cherry Hill, NJ 08003 (US) BONDINELL, William, Edward Wayne, PA 19087 (US) KU, Thomas, Wen-Fu Dresher, PA 19025 (US) SAMANEN, James, Martin Phoenixville, PA 19460 (US) (74) Representative: Valentine, Jill Barbara, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)