(19)

(11)

EP 0 571 524 A1

(12)

(43) Date of publication: 01.12.1993 Bulletin 1993/48 (21) Application number: 92906781.0 (22) Date of filing: 28.01.1992

(51) International Patent Classification (IPC):  C07D 213/ 28( . ) A61K 31/ 4427( . ) A61K 31/ 505( . ) C01B 15/ 10( . ) C07D 401/ 06( . ) C07D 405/ 06( . ) C11D 3/ 39( . ) C11D 7/ 38( . ) A61K 31/ 44( . ) A61K 31/ 443( . ) A61P 31/ 04( . ) C07D 213/ 70( . ) C07D 403/ 06( . ) C07D 521/ 00( . ) C11D 3/ 395( . ) (86) International application number: PCT/US1992/000664 (87) International publication number: WO 1992/013798 (20.08.1992 Gazette 1992/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 06.02.1991 GB 19910002507 (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati, Ohio 45202 (US)	(72) Inventors: AGAR, Joseph Thomas Henry Newcastle upon Tyne NE5 1PB (GB) FRASER, Douglas, Gilbert Newcastle upon Tyne NE2 3HR (GB) (74) Representative: Canonici, Jean-Jacques, et al  Procter & Gamble European Technical Center N.V. Temselaan 100 B-1853 Strombeek-Bever B-1853 Strombeek-Bever (BE)