(19)
(11) EP 0 571 973 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
08.06.1994 Bulletin 1994/23

(43) Date of publication A2:
01.12.1993 Bulletin 1993/48

(21) Application number: 93108492.5

(22) Date of filing: 26.05.1993
(51) International Patent Classification (IPC)5: A61K 31/20, A61K 9/20, A61K 9/28
(84) Designated Contracting States:
BE DE ES FR GB IT NL PT

(30) Priority: 29.05.1992 JP 161785/92

(71) Applicant: NIKKEN CHEMICALS CO., LTD.
Tokyo (JP)

(72) Inventors:
  • Ukigaya, Tadashi
    Kawagoe-shi, Saitama (JP)
  • Endoh, Hirotaka
    Kawagoe-shi, Saitama (JP)

(74) Representative: VOSSIUS & PARTNER 
Postfach 86 07 67
81634 München
81634 München (DE)


(56) References cited: : 
   
       


    (54) Slow-release sodium valproate tablets


    (57) A slow-release sodium valproate tablet with a coating layer, obtained by coating a core containing sodium valproate with a coating agent comprising ethyl cellulose having silicic acid anhydride dispersed therein. The slow-release tablets, while having a relatively small size, maintain a stable dissolution rate without being influenced by pH conditions to stably maintain the blood concentration of active agent over an extended period of time.





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