(19)

(11)

EP 0 572 455 A1

(12)

(43) Date of publication: 08.12.1993 Bulletin 1993/49 (21) Application number: 92904509.0 (22) Date of filing: 17.02.1992

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) A61K 31/ 4425( . ) A61K 31/ 443( . ) A61K 31/ 47( . ) A61K 31/ 517( . ) A61P 9/ 00( . ) A61P 9/ 10( . ) A61P 13/ 02( . ) A61P 25/ 18( . ) A61P 25/ 28( . ) A61P 43/ 00( . ) C07D 213/ 69( . ) C07D 213/ 82( . ) C07D 215/ 22( . ) C07D 239/ 36( . ) C07D 239/ 70( . ) C07D 401/ 12( . ) C07D 405/ 06( . ) C07D 471/ 04( . ) A61K 31/ 4418( . ) A61K 31/ 4427( . ) A61K 31/ 455( . ) A61K 31/ 505( . ) A61P 5/ 38( . ) A61P 9/ 08( . ) A61P 9/ 12( . ) A61P 15/ 00( . ) A61P 25/ 20( . ) A61P 27/ 02( . ) C07D 213/ 64( . ) C07D 213/ 80( . ) C07D 213/ 85( . ) C07D 239/ 34( . ) C07D 239/ 52( . ) C07D 401/ 10( . ) C07D 403/ 10( . ) C07D 405/ 14( . ) (86) International application number: PCT/GB1992/000280 (87) International publication number: WO 1992/014714 (03.09.1992 Gazette 1992/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL PT SE (30) Priority: 16.02.1991 GB 19910003326 15.06.1991 GB 19910012975 21.06.1991 GB 19910013492 10.07.1991 GB 19910014829 28.09.1991 GB 19910020677 14.11.1991 GB 19910024168 26.11.1991 GB 19910025059 12.12.1991 GB 19910026575 12.12.1991 GB 19910026573 04.01.1992 GB 19920000101 (71) Applicant: FISONS plc Ipswich Suffolk IP1 1QH (GB)

(72) Inventors: BANTICK, John Raymond Loughborough Leicestershire LE12 5HG (GB) McINALLY, Thomas Loughborough Leicestershire LE11 2SN (GB) TINKER, Alan Charles Loughborough Leicestershire LE11 0JR (GB) HIRST, Simon Christopher West Bridgford Nottingham NG2 5JJ (GB) (74) Representative: Wright, Robert Gordon McRae  FISONS plc 12 Derby Road Loughborough Leicestershire LE11 0BB Loughborough Leicestershire LE11 0BB (GB)