(19)

(11)

EP 0 572 541 A1

(12)

(43) Date of publication: 08.12.1993 Bulletin 1993/49 (21) Application number: 92907392.0 (22) Date of filing: 21.02.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 14/ 705( . ) (86) International application number: PCT/US1992/001370 (87) International publication number: WO 1992/014482 (03.09.1992 Gazette 1992/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 22.02.1991 US 19910662227 (71) Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02139 (US)	(72) Inventor: KRIEGER, Monty Needham, MA 02194 (US) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)